Recurrent IVF Failure Is Depressing – Don’t Give Up!

One cycle after another… Again and again …. When you fail to conceive… it is frustrating….exhausting- physically, mentally and emotionally! Isn’t it? You are desperate to have a baby! You are facing IVF failure for fourth or fifth time! You are now emotionally drained! You are looking for the answers!

failed IVF cycle could be because of two reasons

1) Embryos are not of good quality 2) Problem with endometrial receptivity.

Successful embryo implantation depends on the health of the embryo. In women with PCOD, the oocyte and embryo quality are significantly compromised and therefore, supplements are used to improve the quality; followed by aggressive super-ovulation to grow as many eggs as possible. The embryos formed may fail to implant because they may be chromosomally abnormal (even though they look normal). Research shows that the chances of chromosomal abnormalities even in good looking embryos are as high as 50%. Genetic abnormalities of the male or female, defective sperm, or zona (outer surface of egg) hardening – affect the health of embryo and can lead to IVF failure.

When there is embryonic problem, we at Morpheus IVF recommend growing of embryos to blastocyst stage (rather than transferring them on Day 2 or 3). This is the best way of ensuring that the embryos are competent. Given the state of art technology and highly skilled embryologists at work in Morpheus, this is the best approach to make sure that the embryos are viable. If the embryos do not grow up to the blastocyst stage in the incubator in vitro, this means the reason for recurrent implantation failure is quite likely to be an embryo problem. This is mostly true for the failed IVF patients who have undergone Day 2 or Day 3 transfers, and the earlier IVF clinic has not tried to grow their embryos upto the blastocyst stage.

Endometrial receptivity (at the time when the uterus is ready to receive the embryo) is another cause of the recurrent IVF failure. Embryo cannot attach and implant to the thin and unresponsive endometrium (uterine lining). Hormonal medications are given to the patient to increase the uterine thickness and prepare it for implantation. Our approach is to freeze embryos when uterine lining is thin and transfer them when it is thick and ready to receive the embryo/embryos.

A functioning and receptive uterine lining is crucial for the embryo implantation. During the menstrual cycle the uterine lining undergoes many changes- which prepares itself for the reception of embryo, and ultimately for successful implantation. Once the endometrium is thick and receptive, the embryo can attach to the uterine lining and can finally implant. This crucial stage lasts for few days and is referred to as the “window of implantation”. To reach this stage, the endometrium must proliferate, increase in thickness and then, after ovulation, successfully respond to progesterone and become receptive. At Morpheus IVF, we carry out ultrasound examinations of the thickness and appearance of the endometrial lining for assessing the changes occurring within to predict the successful implantation.

We at Morpheus IVF, also offer adjuvant therapies to increase the chances of pregnancy in recurrent IVF failure patients.

This is why getting your treatment at Morpheus IVF clinic is a great idea if you have a history of failed, multiple IVF cycles. Our team is constantly assessing the latest evidence in fertility treatments for improving your chances of pregnancy. Good news is- we offer two cycles of IVF at one cost of 1 Lakh + drug cost under DYC program at all our PAN India centers.