Role of Spermatozoa in the Etiology of Miscarriage

Approximately one in every seven pregnancies ends in miscarriage. Yet despite thorough evaluation, the etiology of recurrent miscarriage cannot be determined in at least 50% of cases. Approximately 0.6% of sperm from normal ejaculates possess aneuploid sets of chromosomes, although this incidence increases to 6% with disordered spermatogenesis, as reflected in severe oligospermia, and to 14% in nonobstructive azoospermia. Paternal aging affects the sperm epigenome, which potentially could impact embryonic development. These data raise the need for future investigation to confirm the role of spermatozoa in miscarriage.

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